Pharmacy and Poisons Board: Applications

Protocol No.	Study Title	Principal Investigator(s)	Name of Site / County	Pages	Clear
Application Submission Dates-to- clear!

#	Protocol No	Study Title	Investigator(s) & Site(s)
51.	ECCT/12/12/01	A pilot study to optimise controlled human malaria infections in humans with varying degrees of prior exposure to malaria using P. falciparum sporozoites administered by needle and syringe	Principal Investigator(s) 1. Bernhards Ogutu 2. Kevin Marsh Site(s) in Kenya Kenya Medical Research Institute, Centre for Clinical Research, Nairobi	View

History
+
Request History
4 previous requests available
====
Session
+
Session
- Config(array)
  userAgent2063a0f9ea26ea06ae09c8cfbae7cd53
  time1728847207
  countdown10
====
Request
+
Request

Cake Params
- plugin(null)
- controllerapplications
- actionindex
- named(array)
  page11
  trial_human_pharmacology1
- pass(empty)
- isAjax(false)
- paging(array)
  Application(array)
  page11
  current1
  count51
  prevPage(true)
  nextPage(false)
  pageCount11
  order(array)
  Application.createddesc
  limit5
  options(array)
  page11
  paramTypenamed
Post data
- Application(array)
  trial_human_pharmacology1
Query string

No querystring data.

Cookie

To view Cookies, add CookieComponent to Controller

Current Route
- keys(array)
  0controller
  1action
- options(empty)
- defaults(array)
  plugin(null)
- template/:controller/:action/*
====

Sql Logs

default

Total Time: 15 ms
Total Queries: 6 queries

Query	Affected	Num. rows	Took (ms)	Actions
SELECT `Application`.`id`, `Application`.`user_id`, `Application`.`trial_status_id`, `Application`.`abstract_of_study`, `Application`.`study_title`, `Application`.`laymans_summary`, `Application`.`short_title`, `Application`.`protocol_no`, `Application`.`version_no`, `Application`.`date_of_protocol`, `Application`.`study_drug`, `Application`.`disease_condition`, `Application`.`product_type_biologicals`, `Application`.`product_type_proteins`, `Application`.`product_type_immunologicals`, `Application`.`product_type_vaccines`, `Application`.`product_type_hormones`, `Application`.`product_type_toxoid`, `Application`.`product_type_chemical`, `Application`.`product_type_medical_device`, `Application`.`product_type_chemical_name`, `Application`.`product_type_medical_device_name`, `Application`.`comparator`, `Application`.`comparator_name`, `Application`.`comparator_registered`, `Application`.`comparator_countries`, `Application`.`ecct_not_applicable`, `Application`.`ecct_ref_number`, `Application`.`email_address`, `Application`.`applicant_covering_letter`, `Application`.`applicant_protocol`, `Application`.`applicant_patient_information`, `Application`.`applicant_investigators_brochure`, `Application`.`applicant_investigators_cv`, `Application`.`applicant_signed_declaration`, `Application`.`applicant_financial_declaration`, `Application`.`applicant_gmp_certificate`, `Application`.`applicant_indemnity_cover`, `Application`.`applicant_opinion_letter`, `Application`.`applicant_approval_letter`, `Application`.`applicant_statement`, `Application`.`applicant_participating_countries`, `Application`.`applicant_addendum`, `Application`.`applicant_fees`, `Application`.`applicant_complete_form`, `Application`.`applicant_impd`, `Application`.`applicant_prev_data`, `Application`.`applicant_stability_data`, `Application`.`applicant_analysis_cert`, `Application`.`applicant_pictorial_sample`, `Application`.`applicant_gcp_training`, `Application`.`applicant_dsmb_charter`, `Application`.`applicant_detailed_budget`, `Application`.`applicant_indemnity_pi`, `Application`.`applicant_practice_license`, `Application`.`applicant_registration_ctr`, `Application`.`applicant_pan_african`, `Application`.`applicant_hard_copies`, `Application`.`applicant_signed_checklist`, `Application`.`statistical_analysis_plan`, `Application`.`applicant_contractual_agreement`, `Application`.`declaration_applicant`, `Application`.`declaration_date1`, `Application`.`declaration_principal_investigator`, `Application`.`declaration_date2`, `Application`.`placebo_present`, `Application`.`study_objectives`, `Application`.`principal_inclusion_criteria`, `Application`.`principal_exclusion_criteria`, `Application`.`primary_end_points`, `Application`.`scope_diagnosis`, `Application`.`scope_prophylaxis`, `Application`.`scope_therapy`, `Application`.`scope_safety`, `Application`.`scope_efficacy`, `Application`.`scope_pharmacokinetic`, `Application`.`scope_pharmacodynamic`, `Application`.`scope_bioequivalence`, `Application`.`scope_dose_response`, `Application`.`scope_pharmacogenetic`, `Application`.`scope_pharmacogenomic`, `Application`.`scope_pharmacoecomomic`, `Application`.`scope_others`, `Application`.`scope_others_specify`, `Application`.`trial_human_pharmacology`, `Application`.`trial_administration_humans`, `Application`.`trial_bioequivalence_study`, `Application`.`trial_other`, `Application`.`trial_other_specify`, `Application`.`trial_therapeutic_exploratory`, `Application`.`trial_therapeutic_confirmatory`, `Application`.`trial_therapeutic_use`, `Application`.`design_controlled`, `Application`.`site_capacity`, `Application`.`staff_numbers`, `Application`.`other_details_explanation`, `Application`.`other_details_regulatory_notapproved`, `Application`.`other_details_regulatory_approved`, `Application`.`other_details_regulatory_rejected`, `Application`.`other_details_regulatory_halted`, `Application`.`estimated_duration`, `Application`.`design_controlled_randomised`, `Application`.`design_controlled_open`, `Application`.`design_controlled_single_blind`, `Application`.`design_controlled_double_blind`, `Application`.`design_controlled_parallel_group`, `Application`.`design_controlled_cross_over`, `Application`.`design_controlled_other`, `Application`.`design_controlled_specify`, `Application`.`design_controlled_comparator`, `Application`.`design_controlled_other_medicinal`, `Application`.`design_controlled_placebo`, `Application`.`design_controlled_medicinal_other`, `Application`.`design_controlled_medicinal_specify`, `Application`.`single_site_member_state`, `Application`.`location_of_area`, `Application`.`single_site_physical_address`, `Application`.`single_site_contact_person`, `Application`.`single_site_telephone`, `Application`.`multiple_sites_member_state`, `Application`.`multiple_countries`, `Application`.`multiple_member_states`, `Application`.`number_of_sites`, `Application`.`multi_country_list`, `Application`.`data_monitoring_committee`, `Application`.`total_enrolment_per_site`, `Application`.`total_participants_worldwide`, `Application`.`population_less_than_18_years`, `Application`.`population_utero`, `Application`.`population_preterm_newborn`, `Application`.`population_newborn`, `Application`.`population_infant_and_toddler`, `Application`.`population_children`, `Application`.`population_adolescent`, `Application`.`population_above_18`, `Application`.`population_adult`, `Application`.`population_elderly`, `Application`.`gender_female`, `Application`.`gender_male`, `Application`.`subjects_healthy`, `Application`.`subjects_patients`, `Application`.`subjects_vulnerable_populations`, `Application`.`subjects_women_child_bearing`, `Application`.`subjects_women_using_contraception`, `Application`.`subjects_pregnant_women`, `Application`.`subjects_nursing_women`, `Application`.`subjects_emergency_situation`, `Application`.`subjects_incapable_consent`, `Application`.`subjects_specify`, `Application`.`subjects_others`, `Application`.`subjects_others_specify`, `Application`.`investigator1_given_name`, `Application`.`investigator1_middle_name`, `Application`.`investigator1_family_name`, `Application`.`investigator1_qualification`, `Application`.`investigator1_professional_address`, `Application`.`investigator1_telephone`, `Application`.`investigator1_email`, `Application`.`organisations_transferred_`, `Application`.`number_participants`, `Application`.`notification`, `Application`.`approval_date`, `Application`.`submitted`, `Application`.`deleted`, `Application`.`deleted_date`, `Application`.`deactivated`, `Application`.`date_submitted`, `Application`.`unsubmitted`, `Application`.`initial_date_submitted`, `Application`.`admin_stopped`, `Application`.`admin_stopped_reason`, `Application`.`approved`, `Application`.`approved_reason`, `Application`.`final_report`, `Application`.`implication_results`, `Application`.`quantity_imported`, `Application`.`quantity_dispensed`, `Application`.`quantity_destroyed`, `Application`.`quantity_exported`, `Application`.`balance_site`, `Application`.`final_date`, `Application`.`modified`, `Application`.`created`, `Application`.`total_sites`, `Application`.`ecitizen_invoice` FROM `ctr`.`applications` AS `Application` WHERE `Application`.`trial_human_pharmacology` = '1' AND `Application`.`submitted` = '1' AND `Application`.`approved` = 2 AND `Application`.`deactivated` = '0' AND `Application`.`deleted` = '0' ORDER BY `Application`.`created` desc LIMIT 50, 5	1	1	12	maybe slow
SELECT `InvestigatorContact`.`id`, `InvestigatorContact`.`application_id`, `InvestigatorContact`.`given_name`, `InvestigatorContact`.`middle_name`, `InvestigatorContact`.`family_name`, `InvestigatorContact`.`qualification`, `InvestigatorContact`.`professional_address`, `InvestigatorContact`.`telephone`, `InvestigatorContact`.`email`, `InvestigatorContact`.`created`, `InvestigatorContact`.`modified` FROM `ctr`.`investigator_contacts` AS `InvestigatorContact` WHERE `InvestigatorContact`.`application_id` = (60)	2	2	1	maybe slow
SELECT `SiteDetail`.`id`, `SiteDetail`.`application_id`, `SiteDetail`.`county_id`, `SiteDetail`.`site_name`, `SiteDetail`.`physical_address`, `SiteDetail`.`contact_details`, `SiteDetail`.`contact_person`, `SiteDetail`.`site_capacity`, `SiteDetail`.`misc`, `SiteDetail`.`created`, `SiteDetail`.`modified` FROM `ctr`.`site_details` AS `SiteDetail` WHERE `SiteDetail`.`application_id` = (60)	1	1	1
SELECT `Sponsor`.`id`, `Sponsor`.`application_id`, `Sponsor`.`sponsor`, `Sponsor`.`sponsor_type`, `Sponsor`.`contact_person`, `Sponsor`.`address`, `Sponsor`.`telephone_number`, `Sponsor`.`fax_number`, `Sponsor`.`cell_number`, `Sponsor`.`email_address`, `Sponsor`.`created`, `Sponsor`.`modified` FROM `ctr`.`sponsors` AS `Sponsor` WHERE `Sponsor`.`application_id` = (60)	1	1	1
SELECT COUNT(*) AS `count` FROM `ctr`.`applications` AS `Application` WHERE `Application`.`trial_human_pharmacology` = '1' AND `Application`.`submitted` = '1' AND `Application`.`approved` = 2 AND `Application`.`deactivated` = '0' AND `Application`.`deleted` = '0'	1	1	0
SELECT `TrialStatus`.`id`, `TrialStatus`.`name` FROM `ctr`.`trial_statuses` AS `TrialStatus` WHERE 1 = 1	9	9	0

Query Explain:

Click an "Explain" link above, to see the query explanation.

====

Timer

Memory

Peak Memory Use 11.78 MB

Message	Memory use
Component initialization	2.44 MB
Controller action start	3.71 MB
Controller render start	4.30 MB
View render complete	5.05 MB

Timers

Total Request Time: 134 (ms)

Message	Time in ms	Graph
Core Processing (Derived from $_SERVER["REQUEST_TIME"])	45.73
Event: Controller.initialize	1.71
Event: Controller.startup	0.72
Controller action	32.04
Event: Controller.beforeRender	21.22
» Processing toolbar data	21.12
Rendering View	9.64
» Event: View.beforeRender	0.04
» Rendering APP/View/Applications/index.ctp	0.24
» » Rendering APP/View/Elements/google-recommend.ctp	0.06
» Rendering APP/View/Elements/application/public_index.ctp	6.54
» Event: View.afterRender	0.02
» Event: View.beforeLayout	0.02
» Rendering APP/View/Layouts/default.ctp	2.30
» » Rendering APP/View/Elements/google-analytics.ctp	0.08
Event: View.afterLayout	0.00

====

Log
+

Logs

There were no log entries made this request

====
Variables
+
View Variables
- trial_statuses(array)
 1Recruiting
 2Not yet recruiting
 3Suspended
 4Stopped
 5Completed
 6In follow-up
 7Analysing
 8Writing-up
 9Application withdrawn
- applications(array)
 0(array)
 Application(array)
 id60
 user_id51
 trial_status_id(null)
 abstract_of_study\n \n\n Controlled human malaria infection (CHMI) is an important tool for assessment of the efficacy of novel malaria vaccines and drugs. As CHMI trials are carried out in a controlled environment, they allow unprecedented detailed evaluation of parasite growth and immunological responses, providing essential information for vaccine and drug development.\n\n To date, modern CHMI studies have only been performed in countries where malaria is not endemic and involved volunteers who are malaria naïve. However, CHMI studies involving volunteers with prior exposure to malaria could be a valuable tool to accelerate malaria vaccine development.\n\n The ability to perform CHMI studies in Africa would increase the international capacity for efficacy testing of malaria vaccines and allow earlier assessment of vaccine efficacy in the target, African population. CHMI trial centres in Africa would allow malaria endemic countries, which have the most to gain from malaria research, to influence the research agenda, to operate independently and to exercise ownership over key research pertinent to their health priorities.\n\n We propose to conduct a CHMI study of 28 healthy adults with varying degrees of prior exposure to malaria in Kenya. We will assess parasite growth dynamics post CHMI and examine the relationship between this and laboratory assays of functional immunity to P. falciparum. \n
 study_title\n \n\n A pilot study to optimise controlled human malaria infections in humans with varying degrees of prior exposure to malaria using P. falciparum sporozoites administered by needle and syringe\n
 laymans_summary(null)
 short_title(null)
 protocol_noECCT/12/12/01
 version_no6.0
 date_of_protocol17-11-2012
 study_drugPurified Plasmodium Falciparum Sporozoites
 disease_conditionMalaria
 product_type_biologicals1
 product_type_proteins0
 product_type_immunologicals0
 product_type_vaccines1
 product_type_hormones0
 product_type_toxoid0
 product_type_chemical0
 product_type_medical_device0
 product_type_chemical_name
 product_type_medical_device_name
 comparator(null)
 comparator_name(null)
 comparator_registered(null)
 comparator_countries(null)
 ecct_not_applicable0
 ecct_ref_number
 email_addresseajuma@kemri.org
 applicant_covering_letter1
 applicant_protocol1
 applicant_patient_information1
 applicant_investigators_brochure1
 applicant_investigators_cv1
 applicant_signed_declaration1
 applicant_financial_declaration1
 applicant_gmp_certificate1
 applicant_indemnity_cover1
 applicant_opinion_letter1
 applicant_approval_letter1
 applicant_statement1
 applicant_participating_countries0
 applicant_addendum0
 applicant_fees1
 applicant_complete_form(null)
 applicant_impd(null)
 applicant_prev_data(null)
 applicant_stability_data(null)
 applicant_analysis_cert(null)
 applicant_pictorial_sample(null)
 applicant_gcp_training(null)
 applicant_dsmb_charter(null)
 applicant_detailed_budget(null)
 applicant_indemnity_pi(null)
 applicant_practice_license(null)
 applicant_registration_ctr(null)
 applicant_pan_african(null)
 applicant_hard_copies(null)
 applicant_signed_checklist(null)
 statistical_analysis_plan(null)
 applicant_contractual_agreement(null)
 declaration_applicantDr. Elizabeth Juma
 declaration_date111-03-2013
 declaration_principal_investigatorDr. Bernhards Ogutu
 declaration_date211-03-2013
 placebo_presentNo
 study_objectives(null)
 principal_inclusion_criteria\n \n<ul>\n <li>\n Healthy adults aged 18 to 40 years.</li>\n <li>\n Minimum of 4 completed years (Form 4) of secondary education (Students in tertiary institutions will need to produce a student ID card provided by the school; other volunteers will need to produce their form 4 completion certificates).</li>\n <li>\n Able and willing (in the Investigator’s opinion) to comply with all study requirements.</li>\n <li>\n Informed consent to undergo CHMI.</li>\n <li>\n Answer all questions on the informed consent questionnaire correctly.</li>\n <li>\n Willingness to take a course of curative anti-malaria medication.</li>\n <li>\n Agreement to stay in an in-patient unit during a part of the study (from day of administration of PfSPZ Challenge until completion of curative course of atovaquone/ proguanil hydrochloride given either at malaria diagnosis or day 21 post administration of PfSPZ Challenge).</li>\n <li>\n Use of effective method of contraception for duration of study (women only).</li>\n</ul>\n
 principal_exclusion_criteria\n \n<ul>\n <li>\n PCR positive for P. falciparum parasites at screening.</li>\n <li>\n Use systemic antibiotics with known antimalarial activity within 30 days of administration of PfSPZ Challenge (e.g. trimethoprim-sulfamethoxazole, doxycycline, tetracycline, clindamycin, erythromycin, fluoroquinolones and azithromycin).</li>\n <li>\n Receipt of an investigational product in the 30 days preceding enrolment, or planned receipt during the study period.</li>\n <li>\n Current participation in another clinical trial or recent participation within 12 weeks of enrolment.</li>\n <li>\n Prior receipt of an investigational malaria vaccine.</li>\n <li>\n Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection; asplenia; recurrent, severe infections and chronic (more than 14 days) immunosuppressant medication within the past 6 months (inhaled and topical steroids are allowed).</li>\n <li>\n Use of immunoglobulins or blood products within 3 months prior to enrolment.</li>\n <li>\n Haemoglobinopathy (sickle-cell trait) deemed to interfere with study endpoints</li>\n <li>\n A history of allergic disease or reactions likely to be exacerbated by malaria infection.</li>\n <li>\n Contraindications to atovaquone/proguanil hydrochloride.</li>\n <li>\n History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ).</li>\n <li>\n History of serious psychiatric condition that may affect participation in the study.</li>\n <li>\n Any other serious chronic illness requiring hospital specialist supervision.</li>\n <li>\n Women only; pregnancy, intention to become pregnant or breast-feeding during study.</li>\n <li>\n Suspected or known current alcohol abuse.</li>\n <li>\n Suspected or known injecting drug abuse.</li>\n <li>\n Seropositive for hepatitis B surface antigen (HBsAg).</li>\n <li>\n Seropositive for hepatitis C virus (antibodies to HCV) with PCR positive for Hepatitis C.</li>\n <li>\n Positive family history in 1st and 2nd degree relatives < 50 years old for cardiac disease.</li>\n <li>\n Any clinically significant abnormal finding on biochemistry or haematology blood tests, urinalysis or clinical examination.</li>\n <li>\n Any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data.</li>\n</ul>\n\n \n
 primary_end_points\n \n\n Primary Endpoint \n\n The infectivity of PfSPZ Challenge in healthy Kenyan adults assessed using thick film microscopy and highly sensitive PCR for P. falciparum DNA.\n\n \n\n Secondary Endpoint\n\n Volunteers’ natural immunity to P. falciparum assessed by comparing parasite growth dynamics between volunteers with maximum and minimal prior exposure to malaria following CHMI. \n
 scope_diagnosis0
 scope_prophylaxis0
 scope_therapy0
 scope_safety1
 scope_efficacy1
 scope_pharmacokinetic0
 scope_pharmacodynamic0
 scope_bioequivalence0
 scope_dose_response0
 scope_pharmacogenetic0
 scope_pharmacogenomic0
 scope_pharmacoecomomic0
 scope_others0
 scope_others_specify
 trial_human_pharmacology1
 trial_administration_humans0
 trial_bioequivalence_study0
 trial_other1
 trial_other_specifyPotential Vaccine Candidate
 trial_therapeutic_exploratory0
 trial_therapeutic_confirmatory0
 trial_therapeutic_use0
 design_controlledNo
 site_capacity(null)
 staff_numbers\n \n\n Site: KEMRI-CCR has a well-equipped in-patient facility for clinical trials with 12 nursing officers and laboratory personnel. It has emergency resuscitation facilities but will rely on Nairobi hospital for emergency care if needed.\n\n Core Study team:\n\n Dr. Susanne Sheehy, MBChB, MRCP, DTM&H (PhD Student and Vaccine Research Fellow)\n\n Dr. Elizabeth Juma MBChB, MMed (Study Coordinator), Clinical Trialist\n\n Dr. Patricia Njuguna MBChB, MMed (Clinical Trials Coordinator, KEMRI-WT Kilifi, PI RTS,S vaccine study\n\n Dr. Faith Osier, MBChB, MRCP, PhD (Clinical Immunologist)\n\n Dr. Catherine Molyneux, PhD (Social Scientist)\n\n Laboratories\n\n KEMRI-Wellcome Trust Centre in Kilifi will conduct all immunological studies\n
 other_details_explanation\n \n\n The study is being conducted in Kenya and not in the UK because:\n\n 1. The disease of interest is not a public health problem in the sponsor’s host country. Efforts to develop novel control measures must ultimately be developed in endemic countries among populations likely to benefit from them\n\n 2. Of building KEMRI'sinstitutional capacity to conduct controlled human malaria infections and phase 1 vaccine trials\n
 other_details_regulatory_notapproved\n None\n
 other_details_regulatory_approved\n \n\n Kenya Medical Research Institute Ethics Research Committee 18th January 2013<o:p></o:p>\n\n Oxford Tropical Research Ethics Committee REF: 161-12 29th November 2012 <o:p></o:p>\n
 other_details_regulatory_rejected\n None\n
 other_details_regulatory_halted\n Not Applicable\n
 estimated_duration12 months with 3 months of follow-up for study participants
 design_controlled_randomised
 design_controlled_open
 design_controlled_single_blind
 design_controlled_double_blind
 design_controlled_parallel_group
 design_controlled_cross_over
 design_controlled_other
 design_controlled_specify
 design_controlled_comparator
 design_controlled_other_medicinal
 design_controlled_placebo
 design_controlled_medicinal_other
 design_controlled_medicinal_specify
 single_site_member_stateYes
 location_of_areaKenya Medical Research Institute, Centre for Clinical Research, Nairobi
 single_site_physical_address(null)
 single_site_contact_person(null)
 single_site_telephone(null)
 multiple_sites_member_stateNo
 multiple_countriesNo
 multiple_member_states
 number_of_sites
 multi_country_list
 data_monitoring_committeeYes
 total_enrolment_per_site28
 total_participants_worldwide28
 population_less_than_18_yearsNo
 population_uteroNo
 population_preterm_newbornNo
 population_newbornNo
 population_infant_and_toddlerNo
 population_childrenNo
 population_adolescentNo
 population_above_18Yes
 population_adultYes
 population_elderlyNo
 gender_female1
 gender_male1
 subjects_healthyYes
 subjects_patientsNo
 subjects_vulnerable_populationsNo
 subjects_women_child_bearingNo
 subjects_women_using_contraceptionNo
 subjects_pregnant_womenNo
 subjects_nursing_womenNo
 subjects_emergency_situationNo
 subjects_incapable_consentNo
 subjects_specify
 subjects_othersNo
 subjects_others_specify
 investigator1_given_nameBernhards
 investigator1_middle_name
 investigator1_family_nameOgutu
 investigator1_qualificationMBChB, MMed, PhD
 investigator1_professional_addressKenya Medical Research Institute – Centre for Clinical Research, P. O. Box 20778-00200 Nairobi
 investigator1_telephone(null)
 investigator1_email(null)
 organisations_transferred_No
 number_participants28
 notification\n None\n
 approval_date18-01-2013
 submitted1
 deleted0
 deleted_date(null)
 deactivated0
 date_submitted12-03-2013
 unsubmitted0
 initial_date_submitted(null)
 admin_stopped0
 admin_stopped_reason(null)
 approved2
 approved_reason
 final_report(null)
 implication_results(null)
 quantity_imported(null)
 quantity_dispensed(null)
 quantity_destroyed(null)
 quantity_exported(null)
 balance_site(null)
 final_date(null)
 modified2013-04-05 11:39:28
 created2013-03-07 14:55:20
 total_sites(null)
 ecitizen_invoice(null)
 InvestigatorContact(array)
 0(array)
 id34
 application_id60
 given_nameBernhards
 middle_name
 family_nameOgutu
 qualificationMBChB, MMed, PhD
 professional_addressKenya Medical Research Institute – Centre for Clinical Research, P. O. Box 20778-00200 Nairobi.
 telephone(null)
 email(null)
 created2013-03-07 14:58:42
 modified2013-03-12 12:41:08
 1(array)
 id36
 application_id60
 given_nameKevin
 middle_name
 family_nameMarsh
 qualificationMBChB, MCRP, DTMH
 professional_addressKEMRI and Wellcome Trust Centre for Geographical Medicine Coast, Kilifi
 telephone(null)
 email(null)
 created2013-03-07 15:09:22
 modified2013-03-12 12:41:08
 SiteDetail(array)
 0(array)
 id51
 application_id60
 county_id(null)
 site_name
 physical_address
 contact_details
 contact_person
 site_capacity(null)
 misc(null)
 created2013-03-07 14:58:42
 modified2013-03-12 12:41:08
 County(empty)
 Sponsor(array)
 0(array)
 id28
 application_id60
 sponsorUniversity of Oxford
 sponsor_type(null)
 contact_personElaine Chick, Deputy Head of Clinical Trails and Research Governance
 addressClinical Trials and Research Governance, Joint Research Office, Block 60 Churchill Hospital. Oxford OX3 7LE, United Kingdom
 telephone_number+44 1865 572246
 fax_number+44 1865 572228
 cell_number+44 1865 572246
 email_addressheather.house@admin.ox.ac.uk
 created2013-03-07 14:58:42
 modified2013-03-12 12:41:08
- page_options(array)
 55
 1010
- redir
- $request->data(array)
 Application(array)
 trial_human_pharmacology1
- $this->validationErrors(array)
 Permission(empty)
 Aro(empty)
 Aco(empty)
 Application(empty)
 User(empty)
 TrialStatus(empty)
 InvestigatorContact(empty)
 Sponsor(empty)
 SiteDetail(empty)
 County(empty)
- Loaded Helpers(array)
 0Html
 1Form
 2Session
 3Text
 4Number
 5SimpleGraph
 6Paginator
 7DebugTimer
 8Toolbar
 9HtmlToolbar
====

Environment

App Constants

Constant	Value
MEDIA	'/var/www/html/ctr/app/webroot/media/'
MEDIA_STATIC	'/var/www/html/ctr/app/webroot/media/static/'
MEDIA_FILTER	'/var/www/html/ctr/app/webroot/media/filter/'
MEDIA_TRANSFER	'/var/www/html/ctr/app/webroot/media/transfer/'
MEDIA_URL	'media/'
MEDIA_STATIC_URL	'media/static/'
MEDIA_FILTER_URL	'media/filter/'
MEDIA_TRANSFER_URL	'media/transfer/'
HTTP_HOST	'ctr.pharmacyboardkenya.org'
HTTP_BASE	'http://ctr.pharmacyboardkenya.org'
HTTP_SELF	'/app/webroot/index.php'
HTTP_URI	'/applications/index/page:11/trial_human_pharmacology:1'
CHOWN_PUBLIC	(int) 504
LF	''
NL	''
CR	''
TB	''
BR	' '
WINDOWS	false
FORMAT_DB_DATETIME	'Y-m-d H:i:s'
FORMAT_DB_DATE	'Y-m-d'
FORMAT_DB_TIME	'H:i:s'
DEFAULT_DATETIME	'0000-00-00 00:00:00'
DEFAULT_DATE	'0000-00-00'
DEFAULT_TIME	'00:00:00'
FILES	'/var/www/html/ctr/app/files/'
LOCALE	'/var/www/html/ctr/app/locale/'
CLASS_USER	'User'
VALID_ALPHA	'/^[a-zA-Z]+$/'
VALID_ALPHA_UNDERSCORES	'/^[a-zA-Z_]+$/'
VALID_ALPHA_MINUS_UNDERSCORES	'/^[a-zA-Z_-]+$/'
VALID_ALPHA_WHITESPACES	'/^[a-zA-Z ]+$/'
VALID_ALPHANUMERIC_UNDERSCORES	'/^[\da-zA-Z_]+$/'
VALID_ALPHANUMERIC_MINUS_UNDERSCORES	'/^[\da-zA-Z_-]+$/'
VALID_ALPHANUMERIC_WHITESPACES	'/^[\da-zA-Z ]+$/'
VALID_ALPHANUMERIC_WHITESPACES_UNDERSCORES	'/^[\da-zA-Z _]+$/'
VALID_NUMERIC_UNDERSCORES	'/^[\d_]+$/'
VALID_NUMERIC_WHITESPACES	'/^[\d ]+$/'
VALID_NUMERIC_WHITESPACES_UNDERSCORES	'/^[\d _]+$/'
VALID_INTEGERS	'/^[\d]+$/'
FORMAT_NICE_YMDHMS	'd.m.Y, H:i:s'
FORMAT_NICE_YMDHM	'd.m.Y, H:i'
FORMAT_NICE_YM	'm.Y'
FORMAT_NICE_YMD	'd.m.Y'
FORMAT_NICE_MD	'd.m.'
FORMAT_NICE_D	'd'
FORMAT_NICE_W_NUM	'w'
FORMAT_NICE_W_ABBR	'D'
FORMAT_NICE_W_FULL	'l'
FORMAT_NICE_M	'm'
FORMAT_NICE_M_ABBR	'M'
FORMAT_NICE_M_FULL	'F'
FORMAT_NICE_Y_ABBR	'y'
FORMAT_NICE_Y	'Y'
FORMAT_NICE_HM	'H:i'
FORMAT_NICE_HMS	'H:i:s'
FORMAT_LOCAL_WA_YMDHMS	'%a, %d.%m.%Y, %H:%M:%S'
FORMAT_LOCAL_WF_YMDHMS	'%A, %d.%m.%Y, %H:%M:%S'
FORMAT_LOCAL_WA_YMDHM	'%a, %d.%m.%Y, %H:%M'
FORMAT_LOCAL_WF_YMDHM	'%A, %d.%m.%Y, %H:%M'
FORMAT_LOCAL_YMDHMS	'%d.%m.%Y, %H:%M:%S'
FORMAT_LOCAL_YMDHM	'%d.%m.%Y, %H:%M'
FORMAT_LOCAL_YMD	'%d.%m.%Y'
FORMAT_LOCAL_MD	'%d.%m.'
FORMAT_LOCAL_D	'%d'
FORMAT_LOCAL_W_NUM	'%w'
FORMAT_LOCAL_W_ABBR	'%a'
FORMAT_LOCAL_W_FULL	'%A'
FORMAT_LOCAL_M	'%m'
FORMAT_LOCAL_M_ABBR	'%b'
FORMAT_LOCAL_M_FULL	'%B'
FORMAT_LOCAL_Y_ABBR	'%y'
FORMAT_LOCAL_YMS_ABBR	'%d.%m.%y'
FORMAT_LOCAL_Y	'%Y'
FORMAT_LOCAL_H	'%H'
FORMAT_LOCAL_S	'%S'
FORMAT_LOCAL_HM	'%H:%M'
FORMAT_LOCAL_HMS	'%H:%M:%S'
CHAR_LESS	'<'
CHAR_GREATER	'>'
CHAR_QUOTE	'"'
CHAR_APOSTROPHE	'''
CHAR_ARROWS	'»'
CHAR_ARROWS_R	'»'
CHAR_ARROWS_L	'«'
CHAR_AVERAGE	'Ø'
CHAR_INFIN	'∞'
CHAR_MILL	'‰'
CHAR_PLUSMN	'±'
CHAR_HELLIP	'…'
CHAR_CIRCA	'≈'
CHAR_CHECKBOX_EMPTY	'☐]'
CHAR_CHECKBOX_MAKRED	'☑'
CHAR_CHECKMARK	'✓'
CHAR_CHECKMARK_BOLD	'✔'
CHAR_BALLOT	'✗'
CHAR_BALLOT_BOLD	'✘'
CHAR_ABOUT	'≈'
CHAR_RPIME	'′'
CHAR_DOUBLE_RPIME	'″'

CakePHP Constants

Constant	Value
APP	'/var/www/html/ctr/app/'
APP_DIR	'app'
APPLIBS	'/var/www/html/ctr/app/Lib/'
CACHE	'/var/www/html/ctr/app/tmp/cache/'
CAKE	'/var/www/html/ctr/lib/Cake/'
CAKE_CORE_INCLUDE_PATH	'/var/www/html/ctr/lib'
CORE_PATH	'/var/www/html/ctr/lib/'
CAKE_VERSION	'2.2.2'
CSS	'/var/www/html/ctr/app/webroot/css/'
CSS_URL	'css/'
DS	'/'
FULL_BASE_URL	'https://ctr.pharmacyboardkenya.org'
IMAGES	'/var/www/html/ctr/app/webroot/img/'
IMAGES_URL	'img/'
JS	'/var/www/html/ctr/app/webroot/js/'
JS_URL	'js/'
LOGS	'/var/www/html/ctr/app/tmp/logs/'
ROOT	'/var/www/html/ctr'
TESTS	'/var/www/html/ctr/app/Test/'
TMP	'/var/www/html/ctr/app/tmp/'
VENDORS	'/var/www/html/ctr/vendors/'
WEBROOT_DIR	'webroot'
WWW_ROOT	'/var/www/html/ctr/app/webroot/'

PHP Environment

Environment Variable	Value
Php Version	'5.5.9-1ubuntu4.26'
Redirect Redirect Https	'on'
Redirect Redirect Ssl Tls Sni	'ctr.pharmacyboardkenya.org'
Redirect Redirect Status	'200'
Redirect Https	'on'
Redirect Ssl Tls Sni	'ctr.pharmacyboardkenya.org'
Redirect Status	'200'
Https	'on'
Ssl Tls Sni	'ctr.pharmacyboardkenya.org'
Http User Agent	'CCBot/2.0 (https://commoncrawl.org/faq/)'
Http Accept	'text/html,application/xhtml+xml,application/xml;q=0.9,/;q=0.8'
Http Accept Language	'en-US,en;q=0.5'
Http Accept Encoding	'br,gzip'
Http Host	'ctr.pharmacyboardkenya.org'
Http Connection	'Keep-Alive'
Path	'/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin'
Server Signature	' Apache/2.4.7 (Ubuntu) Server at ctr.pharmacyboardkenya.org Port 443 '
Server Software	'Apache/2.4.7 (Ubuntu)'
Server Name	'ctr.pharmacyboardkenya.org'
Server Addr	'192.168.10.21'
Server Port	'443'
Remote Addr	'3.237.15.145'
Document Root	'/var/www/html/ctr'
Request Scheme	'https'
Context Prefix	''
Context Document Root	'/var/www/html/ctr'
Server Admin	'webmaster@localhost'
Script Filename	'/var/www/html/ctr/app/webroot/index.php'
Remote Port	'45648'
Redirect Url	'/app/webroot/applications/index/page:11/trial_human_pharmacology:1'
Gateway Interface	'CGI/1.1'
Server Protocol	'HTTP/1.1'
Request Method	'GET'
Query String	''
Request Uri	'/applications/index/page:11/trial_human_pharmacology:1'
Script Name	'/app/webroot/index.php'
Php Self	'/app/webroot/index.php'
Request Time Float	(float) 1728818407.663
Request Time	(int) 1728818407

====

Include
+
Included Files

Include Paths
- 0/var/www/html/ctr/app/Plugin/Media/Lib/mm/src
- 1/var/www/html/ctr/lib
- 3/usr/share/php
- 4/usr/share/pear
- 5-> /var/www/html/ctr/lib/Cake/
Included Files
- core(array)
  Behavior(array)
  0CORE/Model/Behavior/TreeBehavior.php
  1CORE/Model/Behavior/ContainableBehavior.php
  2CORE/Model/Behavior/AclBehavior.php
  Cache(array)
  0CORE/Cache/Cache.php
  1CORE/Cache/Engine/FileEngine.php
  2CORE/Cache/CacheEngine.php
  Component(array)
  0CORE/Controller/Component/AclComponent.php
  1CORE/Controller/Component/Acl/DbAcl.php
  2CORE/Controller/Component/Acl/AclInterface.php
  3CORE/Controller/Component/AuthComponent.php
  4CORE/Controller/Component/RequestHandlerComponent.php
  5CORE/Controller/Component/SessionComponent.php
  6CORE/Controller/Component/PaginatorComponent.php
  Config(array)
  0CORE/Config/routes.php
  1CORE/Config/config.php
  Controller(array)
  0CORE/Controller/Controller.php
  1CORE/Controller/ComponentCollection.php
  2CORE/Controller/Component.php
  Datasource(array)
  0CORE/Model/Datasource/CakeSession.php
  1CORE/Model/Datasource/Database/Mysql.php
  2CORE/Model/Datasource/DboSource.php
  3CORE/Model/Datasource/DataSource.php
  Error(array)
  0CORE/Error/exceptions.php
  1CORE/Error/ErrorHandler.php
  I18n(array)
  0CORE/I18n/I18n.php
  1CORE/I18n/L10n.php
  Log(array)
  0CORE/Log/CakeLog.php
  1CORE/Log/LogEngineCollection.php
  2CORE/Log/Engine/FileLog.php
  3CORE/Log/Engine/BaseLog.php
  4CORE/Log/CakeLogInterface.php
  Model(array)
  0CORE/Model/ConnectionManager.php
  1CORE/Model/Permission.php
  2CORE/Model/Model.php
  3CORE/Model/BehaviorCollection.php
  4CORE/Model/Aro.php
  5CORE/Model/AclNode.php
  6CORE/Model/Aco.php
  7CORE/Model/ModelBehavior.php
  Network(array)
  0CORE/Network/CakeRequest.php
  1CORE/Network/CakeResponse.php
  Other(array)
  0CORE/bootstrap.php
  1CORE/basics.php
  2CORE/Core/App.php
  3CORE/Core/Configure.php
  4CORE/Core/CakePlugin.php
  5CORE/Event/CakeEventListener.php
  6CORE/Event/CakeEvent.php
  7CORE/Event/CakeEventManager.php
  8CORE/Core/Object.php
  Routing(array)
  0CORE/Routing/Dispatcher.php
  1CORE/Routing/Filter/AssetDispatcher.php
  2CORE/Routing/DispatcherFilter.php
  3CORE/Routing/Filter/CacheDispatcher.php
  4CORE/Routing/Router.php
  5CORE/Routing/Route/CakeRoute.php
  6CORE/Routing/Route/PluginShortRoute.php
  Utility(array)
  0CORE/Utility/Hash.php
  1CORE/Utility/Inflector.php
  2CORE/Utility/ObjectCollection.php
  3CORE/Utility/Debugger.php
  4CORE/Utility/String.php
  5CORE/Utility/ClassRegistry.php
  6CORE/Utility/Set.php
  7CORE/Utility/Sanitize.php
  View(array)
  0CORE/View/HelperCollection.php
- app(array)
  Behavior(array)
  0APP/Model/Behavior/SoftDeleteBehavior.php
  Config(array)
  0APP/Config/core.php
  1APP/Config/bootstrap.php
  2APP/Config/routes.php
  3APP/Config/database.php
  Controller(array)
  0APP/Controller/ApplicationsController.php
  1APP/Controller/AppController.php
  Model(array)
  0APP/Model/AppModel.php
  1APP/Model/Application.php
  2APP/Model/User.php
  3APP/Model/TrialStatus.php
  4APP/Model/InvestigatorContact.php
  5APP/Model/Sponsor.php
  6APP/Model/SiteDetail.php
  7APP/Model/County.php
  Other(array)
  0APP/webroot/index.php
- plugins(array)
  CakePdf(array)
  Config(array)
  0CakePdf/Config/bootstrap.php
  1CakePdf/Config/routes.php
  CakeResque(array)
  Config(array)
  0CakeResque/Config/bootstrap.php
  Plugin(array)
  0CakeResque/Lib/CakeResque.php
  1CakeResque/vendor/kamisama/php-resque-ex/lib/Resque.php
  2CakeResque/vendor/kamisama/php-resque-ex/lib/Resque/Event.php
  3CakeResque/vendor/kamisama/php-resque-ex/lib/Resque/Exception.php
  DebugKit(array)
  Component(array)
  0DebugKit/Controller/Component/ToolbarComponent.php
  Plugin(array)
  0DebugKit/Lib/DebugMemory.php
  1DebugKit/Lib/Panel/HistoryPanel.php
  2DebugKit/Lib/DebugPanel.php
  3DebugKit/Lib/Panel/SessionPanel.php
  4DebugKit/Lib/Panel/RequestPanel.php
  5DebugKit/Lib/Panel/SqlLogPanel.php
  6DebugKit/Lib/Panel/TimerPanel.php
  7DebugKit/Lib/Panel/LogPanel.php
  8DebugKit/Lib/Log/Engine/DebugKitLog.php
  9DebugKit/Lib/Panel/VariablesPanel.php
  10DebugKit/Lib/Panel/EnvironmentPanel.php
  11DebugKit/Lib/Panel/IncludePanel.php
  12DebugKit/Lib/DebugTimer.php
  Media(array)
  Config(array)
  0Media/Config/bootstrap.php
  Plugin(array)
  0Media/Lib/mm/src/Mime/Type.php
  1Media/Lib/mm/src/Mime/Type/Magic/Adapter/Fileinfo.php
  2Media/Lib/mm/src/Mime/Type/Magic/Adapter.php
  3Media/Lib/mm/src/Mime/Type/Glob/Adapter/Memory.php
  4Media/Lib/mm/src/Mime/Type/Glob/Adapter.php
  5Media/Lib/mm/src/Media/Process.php
  6Media/Lib/mm/src/Media/Info.php
  Search(array)
  Component(array)
  0Search/Controller/Component/PrgComponent.php
  Behavior(array)
  0Search/Model/Behavior/SearchableBehavior.php
  Shim(array)
  Config(array)
  0Shim/Config/bootstrap.php
  Tools(array)
  Config(array)
  0Tools/Config/bootstrap.php
====

Clinical Trial Applications: Filter, Search, and view applications {lang: 'en-GB'}

Request History

Session

Request

Cake Params

Post data

Query string

Cookie

Current Route

Sql Logs

default

Total Time: 15 ms Total Queries: 6 queries

Query Explain:

Memory

Timers

Logs

View Variables

App Constants

CakePHP Constants

PHP Environment

Included Files

Include Paths

Included Files

Clinical Trial Applications: Filter, Search, and view applications

Total Time: 15 ms
Total Queries: 6 queries