Pharmacy and Poisons Board: Applications

Protocol No.	Study Title	Principal Investigator(s)	Name of Site / County	Pages	Clear
Application Submission Dates-to- clear!

#	Protocol No	Study Title	Investigator(s) & Site(s)
501.	ECCT/16/08/02	Zeenk study Zeenk Acceptability Study	Principal Investigator(s) 1. Margaret Oluka 2. David Kimutai 3. Caren Emadu Site(s) in Kenya 1. Mbagathi District Hospital (Nairobi City county) 2. Mama Lucy Kibaki Hospital (Nairobi City county)	View
502.	ECCT/21/05/01	ZAZA study Zinc isotope study: Assessing Zinc absorption from edible insects in young children	Principal Investigator(s) 1. Dr. Alida Melse-Boonstra Melse-Boonstra Site(s) in Kenya Ober-Kamoth sub-county hospital - Level 4 Health Facility	View

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  countdown10
====
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Request

Cake Params
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  options(array)
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  paramTypenamed
Post data
- Application(array)
  approved2
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Sql Logs

default

Total Time: 149 ms
Total Queries: 8 queries

Query	Affected	Num. rows	Took (ms)	Actions
SELECT `Application`.`id`, `Application`.`user_id`, `Application`.`trial_status_id`, `Application`.`abstract_of_study`, `Application`.`study_title`, `Application`.`laymans_summary`, `Application`.`short_title`, `Application`.`protocol_no`, `Application`.`version_no`, `Application`.`date_of_protocol`, `Application`.`study_drug`, `Application`.`disease_condition`, `Application`.`product_type_biologicals`, `Application`.`product_type_proteins`, `Application`.`product_type_immunologicals`, `Application`.`product_type_vaccines`, `Application`.`product_type_hormones`, `Application`.`product_type_toxoid`, `Application`.`product_type_chemical`, `Application`.`product_type_medical_device`, `Application`.`product_type_chemical_name`, `Application`.`product_type_medical_device_name`, `Application`.`comparator`, `Application`.`comparator_name`, `Application`.`comparator_registered`, `Application`.`comparator_countries`, `Application`.`ecct_not_applicable`, `Application`.`ecct_ref_number`, `Application`.`email_address`, `Application`.`applicant_covering_letter`, `Application`.`applicant_protocol`, `Application`.`applicant_patient_information`, `Application`.`applicant_investigators_brochure`, `Application`.`applicant_investigators_cv`, `Application`.`applicant_signed_declaration`, `Application`.`applicant_financial_declaration`, `Application`.`applicant_gmp_certificate`, `Application`.`applicant_indemnity_cover`, `Application`.`applicant_opinion_letter`, `Application`.`applicant_approval_letter`, `Application`.`applicant_statement`, `Application`.`applicant_participating_countries`, `Application`.`applicant_addendum`, `Application`.`applicant_fees`, `Application`.`applicant_complete_form`, `Application`.`applicant_impd`, `Application`.`applicant_prev_data`, `Application`.`applicant_stability_data`, `Application`.`applicant_analysis_cert`, `Application`.`applicant_pictorial_sample`, `Application`.`applicant_gcp_training`, `Application`.`applicant_dsmb_charter`, `Application`.`applicant_detailed_budget`, `Application`.`applicant_indemnity_pi`, `Application`.`applicant_practice_license`, `Application`.`applicant_registration_ctr`, `Application`.`applicant_pan_african`, `Application`.`applicant_hard_copies`, `Application`.`applicant_signed_checklist`, `Application`.`statistical_analysis_plan`, `Application`.`applicant_contractual_agreement`, `Application`.`declaration_applicant`, `Application`.`declaration_date1`, `Application`.`declaration_principal_investigator`, `Application`.`declaration_date2`, `Application`.`placebo_present`, `Application`.`study_objectives`, `Application`.`principal_inclusion_criteria`, `Application`.`principal_exclusion_criteria`, `Application`.`primary_end_points`, `Application`.`scope_diagnosis`, `Application`.`scope_prophylaxis`, `Application`.`scope_therapy`, `Application`.`scope_safety`, `Application`.`scope_efficacy`, `Application`.`scope_pharmacokinetic`, `Application`.`scope_pharmacodynamic`, 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`Application`.`design_controlled_randomised`, `Application`.`design_controlled_open`, `Application`.`design_controlled_single_blind`, `Application`.`design_controlled_double_blind`, `Application`.`design_controlled_parallel_group`, `Application`.`design_controlled_cross_over`, `Application`.`design_controlled_other`, `Application`.`design_controlled_specify`, `Application`.`design_controlled_comparator`, `Application`.`design_controlled_other_medicinal`, `Application`.`design_controlled_placebo`, `Application`.`design_controlled_medicinal_other`, `Application`.`design_controlled_medicinal_specify`, `Application`.`single_site_member_state`, `Application`.`location_of_area`, `Application`.`single_site_physical_address`, `Application`.`single_site_contact_person`, `Application`.`single_site_telephone`, `Application`.`multiple_sites_member_state`, `Application`.`multiple_countries`, `Application`.`multiple_member_states`, `Application`.`number_of_sites`, `Application`.`multi_country_list`, `Application`.`data_monitoring_committee`, `Application`.`total_enrolment_per_site`, `Application`.`total_participants_worldwide`, `Application`.`population_less_than_18_years`, `Application`.`population_utero`, `Application`.`population_preterm_newborn`, `Application`.`population_newborn`, `Application`.`population_infant_and_toddler`, `Application`.`population_children`, `Application`.`population_adolescent`, `Application`.`population_above_18`, `Application`.`population_adult`, `Application`.`population_elderly`, `Application`.`gender_female`, `Application`.`gender_male`, `Application`.`subjects_healthy`, `Application`.`subjects_patients`, `Application`.`subjects_vulnerable_populations`, `Application`.`subjects_women_child_bearing`, `Application`.`subjects_women_using_contraception`, `Application`.`subjects_pregnant_women`, `Application`.`subjects_nursing_women`, `Application`.`subjects_emergency_situation`, `Application`.`subjects_incapable_consent`, `Application`.`subjects_specify`, `Application`.`subjects_others`, `Application`.`subjects_others_specify`, `Application`.`investigator1_given_name`, `Application`.`investigator1_middle_name`, `Application`.`investigator1_family_name`, `Application`.`investigator1_qualification`, `Application`.`investigator1_professional_address`, `Application`.`investigator1_telephone`, `Application`.`investigator1_email`, `Application`.`organisations_transferred_`, `Application`.`number_participants`, `Application`.`notification`, `Application`.`approval_date`, `Application`.`submitted`, `Application`.`deleted`, `Application`.`deleted_date`, `Application`.`deactivated`, `Application`.`date_submitted`, `Application`.`is_child`, `Application`.`unsubmitted`, `Application`.`initial_date_submitted`, `Application`.`admin_stopped`, `Application`.`admin_stopped_reason`, `Application`.`approved`, `Application`.`approved_reason`, `Application`.`final_report`, `Application`.`implication_results`, `Application`.`quantity_imported`, `Application`.`quantity_dispensed`, `Application`.`quantity_destroyed`, `Application`.`quantity_exported`, `Application`.`balance_site`, `Application`.`final_date`, `Application`.`modified`, `Application`.`created`, `Application`.`total_sites`, `Application`.`ecitizen_invoice` FROM `ctr`.`applications` AS `Application` WHERE `Application`.`approved` = 2 AND `Application`.`submitted` = '1' AND `Application`.`deactivated` = '0' AND `Application`.`deleted` = '0' ORDER BY `Application`.`study_title` asc LIMIT 500, 5	2	2	140	maybe slow
SELECT `InvestigatorContact`.`id`, `InvestigatorContact`.`application_id`, `InvestigatorContact`.`given_name`, `InvestigatorContact`.`middle_name`, `InvestigatorContact`.`family_name`, `InvestigatorContact`.`qualification`, `InvestigatorContact`.`professional_address`, `InvestigatorContact`.`telephone`, `InvestigatorContact`.`email`, `InvestigatorContact`.`created`, `InvestigatorContact`.`modified` FROM `ctr`.`investigator_contacts` AS `InvestigatorContact` WHERE `InvestigatorContact`.`application_id` IN (537, 999)	4	4	2	maybe slow
SELECT `SiteDetail`.`id`, `SiteDetail`.`application_id`, `SiteDetail`.`county_id`, `SiteDetail`.`site_name`, `SiteDetail`.`physical_address`, `SiteDetail`.`contact_details`, `SiteDetail`.`contact_person`, `SiteDetail`.`site_capacity`, `SiteDetail`.`misc`, `SiteDetail`.`created`, `SiteDetail`.`modified` FROM `ctr`.`site_details` AS `SiteDetail` WHERE `SiteDetail`.`application_id` IN (537, 999)	3	3	2	maybe slow
SELECT `County`.`id`, `County`.`county_name`, `County`.`created`, `County`.`modified` FROM `ctr`.`counties` AS `County` WHERE `County`.`id` = 47	1	1	0
SELECT `County`.`id`, `County`.`county_name`, `County`.`created`, `County`.`modified` FROM `ctr`.`counties` AS `County` WHERE `County`.`id` = 47	1	1	0
SELECT `Sponsor`.`id`, `Sponsor`.`application_id`, `Sponsor`.`sponsor`, `Sponsor`.`sponsor_type`, `Sponsor`.`contact_person`, `Sponsor`.`address`, `Sponsor`.`telephone_number`, `Sponsor`.`fax_number`, `Sponsor`.`cell_number`, `Sponsor`.`email_address`, `Sponsor`.`created`, `Sponsor`.`modified` FROM `ctr`.`sponsors` AS `Sponsor` WHERE `Sponsor`.`application_id` IN (537, 999)	2	2	1	maybe slow
SELECT COUNT(*) AS `count` FROM `ctr`.`applications` AS `Application` WHERE `Application`.`approved` = 2 AND `Application`.`submitted` = '1' AND `Application`.`deactivated` = '0' AND `Application`.`deleted` = '0'	1	1	4	maybe slow
SELECT `TrialStatus`.`id`, `TrialStatus`.`name` FROM `ctr`.`trial_statuses` AS `TrialStatus` WHERE 1 = 1	9	9	0

1 duplicate queries run.

Query Explain:

Click an "Explain" link above, to see the query explanation.

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Timer

Memory

Peak Memory Use 10.43 MB

Message	Memory use
Component initialization	2.39 MB
Controller action start	3.55 MB
Controller render start	4.32 MB
View render complete	4.80 MB

Timers

Total Request Time: 496 (ms)

Message	Time in ms	Graph
Core Processing (Derived from $_SERVER["REQUEST_TIME"])	118.08
Event: Controller.initialize	3.57
Event: Controller.startup	1.56
Controller action	199.49
Event: Controller.beforeRender	51.66
» Processing toolbar data	51.43
Rendering View	32.71
» Event: View.beforeRender	0.08
» Rendering APP/View/Applications/index.ctp	0.55
» » Rendering APP/View/Elements/google-recommend.ctp	0.15
» Rendering APP/View/Elements/application/public_index.ctp	14.54
» Event: View.afterRender	0.05
» Event: View.beforeLayout	0.05
» Rendering APP/View/Layouts/default.ctp	16.33
» » Rendering APP/View/Elements/google-analytics.ctp	0.23
Event: View.afterLayout	0.00

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Log
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Logs

There were no log entries made this request

====
Variables
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View Variables
- trial_statuses(array)
 1Recruiting
 2Not yet recruiting
 3Suspended
 4Stopped
 5Completed
 6In follow-up
 7Analysing
 8Writing-up
 9Application withdrawn
- applications(array)
 0(array)
 Application(array)
 id537
 user_id342
 trial_status_id(null)
 abstract_of_study\n Oral zinc sulphate solution has a bad taste and therefore children do not accept it easily. This study is required to show that a new formulation of zinc sulphate is better accepted by children. If this is the case, the formulation will improve the management of childhood diarrhoea which is a major cause of morbidity and mortality in Kenya. It is hoped that this study will provide insight on determinants of acceptability and adherence to zinc supplemtantion. This would feed into thee design of interventions that would promote acceptability and eventually reduce the duration and the severity of diarrhoea. If the formulation has a superior acceptability compared to ORS then this would provide insights into the development of better formulations.\n
 study_title\n Zeenk Acceptability Study\n
 laymans_summary(null)
 short_titleZeenk study
 protocol_noECCT/16/08/02
 version_no9/2015
 date_of_protocol09-08-2015
 study_drugZinc sulphate
 disease_conditionAcute dirrhoea
 product_type_biologicals0
 product_type_proteins0
 product_type_immunologicals0
 product_type_vaccines0
 product_type_hormones0
 product_type_toxoid0
 product_type_chemical1
 product_type_medical_device0
 product_type_chemical_nameZinc sulphate
 product_type_medical_device_name
 comparator(null)
 comparator_name(null)
 comparator_registered(null)
 comparator_countries(null)
 ecct_not_applicable0
 ecct_ref_number
 email_addressquality@ucl.co.ke
 applicant_covering_letter1
 applicant_protocol1
 applicant_patient_information1
 applicant_investigators_brochure1
 applicant_investigators_cv1
 applicant_signed_declaration1
 applicant_financial_declaration1
 applicant_gmp_certificate1
 applicant_indemnity_cover1
 applicant_opinion_letter1
 applicant_approval_letter0
 applicant_statement1
 applicant_participating_countries0
 applicant_addendum0
 applicant_fees1
 applicant_complete_form(null)
 applicant_impd(null)
 applicant_prev_data(null)
 applicant_stability_data(null)
 applicant_analysis_cert(null)
 applicant_pictorial_sample(null)
 applicant_gcp_training(null)
 applicant_dsmb_charter(null)
 applicant_detailed_budget(null)
 applicant_indemnity_pi(null)
 applicant_practice_license(null)
 applicant_registration_ctr(null)
 applicant_pan_african(null)
 applicant_hard_copies(null)
 applicant_signed_checklist(null)
 statistical_analysis_plan(null)
 applicant_contractual_agreement(null)
 declaration_applicantDr George Muriithi 0786911530
 declaration_date102-08-2016
 declaration_principal_investigatorDr Faith Apolot Okalebo
 declaration_date202-08-2016
 placebo_presentNo
 study_objectives(null)
 principal_inclusion_criteria\n Diagnosis: Acute diarrhoea not requiring admission<o:p></o:p>\n\n Sex: Male and female<o:p></o:p>\n\n Age: 18-59 months<o:p></o:p>\n\n Care-giver: Ability by the caregiver to comprehend and willingness to sign statement of informed consent. <o:p></o:p>\n
 principal_exclusion_criteria\n Severe dehydration requiring admission\n\n Does not meet any of the inclusion criteria\n
 primary_end_points\n The treatment will be considered to have good acceptability if 80% of the prescribed treatment is taken by at least 70% of the children.\n
 scope_diagnosis0
 scope_prophylaxis0
 scope_therapy0
 scope_safety0
 scope_efficacy0
 scope_pharmacokinetic0
 scope_pharmacodynamic0
 scope_bioequivalence0
 scope_dose_response1
 scope_pharmacogenetic0
 scope_pharmacogenomic0
 scope_pharmacoecomomic0
 scope_others0
 scope_others_specify
 trial_human_pharmacology0
 trial_administration_humans0
 trial_bioequivalence_study0
 trial_other0
 trial_other_specify
 trial_therapeutic_exploratory0
 trial_therapeutic_confirmatory0
 trial_therapeutic_use1
 design_controlledYes
 site_capacity(null)
 staff_numbers\n 10\n
 other_details_explanation\n N/A\n
 other_details_regulatory_notapproved\n N/A\n
 other_details_regulatory_approved\n N/A\n
 other_details_regulatory_rejected\n N/A\n
 other_details_regulatory_halted\n N/A\n
 estimated_duration6 Months
 design_controlled_randomisedNo
 design_controlled_openYes
 design_controlled_single_blindNo
 design_controlled_double_blindNo
 design_controlled_parallel_groupNo
 design_controlled_cross_overYes
 design_controlled_otherNo
 design_controlled_specify
 design_controlled_comparatorORS
 design_controlled_other_medicinalYes
 design_controlled_placeboNo
 design_controlled_medicinal_otherNo
 design_controlled_medicinal_specify
 single_site_member_stateNo
 location_of_area
 single_site_physical_address
 single_site_contact_person
 single_site_telephone
 multiple_sites_member_stateYes
 multiple_countriesNo
 multiple_member_states
 number_of_sites2
 multi_country_list
 data_monitoring_committeeYes
 total_enrolment_per_site300
 total_participants_worldwiden/a
 population_less_than_18_yearsYes
 population_uteroNo
 population_preterm_newbornNo
 population_newbornNo
 population_infant_and_toddlerYes
 population_childrenYes
 population_adolescentNo
 population_above_18No
 population_adultNo
 population_elderlyNo
 gender_female1
 gender_male1
 subjects_healthyNo
 subjects_patientsNo
 subjects_vulnerable_populationsYes
 subjects_women_child_bearingNo
 subjects_women_using_contraceptionNo
 subjects_pregnant_womenNo
 subjects_nursing_womenNo
 subjects_emergency_situationNo
 subjects_incapable_consentYes
 subjects_specifyChildren
 subjects_othersNo
 subjects_others_specify
 investigator1_given_nameFaith
 investigator1_middle_nameApolot
 investigator1_family_nameOkalebo
 investigator1_qualificationB. Pharm, Phd
 investigator1_professional_addressUniversity of Nairobi P O Box 19676 â€“ 00202
 investigator1_telephone0737 434204
 investigator1_emailokalebo@yahoo.com
 organisations_transferred_No
 number_participants600
 notification
 approval_date10-08-2016
 submitted1
 deleted0
 deleted_date(null)
 deactivated0
 date_submitted08-08-2016
 is_child0
 unsubmitted0
 initial_date_submitted(null)
 admin_stopped0
 admin_stopped_reason(null)
 approved2
 approved_reason
 final_report(null)
 implication_results(null)
 quantity_imported(null)
 quantity_dispensed(null)
 quantity_destroyed(null)
 quantity_exported(null)
 balance_site(null)
 final_date(null)
 modified2016-08-10 08:43:23
 created2016-08-01 10:29:07
 total_sites(null)
 ecitizen_invoice(null)
 InvestigatorContact(array)
 0(array)
 id347
 application_id537
 given_nameMargaret
 middle_name
 family_nameOluka
 qualificationB. Pharm, Phd
 professional_addressUniversity of Nairobi P O Box 19676 â€“ 00202 Nairobi, Kenya
 telephone0722 604216
 emailmargaoluka@yahoo.com
 created2016-08-01 10:47:45
 modified2016-08-08 09:39:18
 1(array)
 id348
 application_id537
 given_nameDavid
 middle_name
 family_nameKimutai
 qualificationMBChB, M.Med (Paeds)
 professional_addressMbagathi District Hospital Ngumo Estate
 telephone0722975048
 emaildkimutaidr@yahoo.com
 created2016-08-01 10:47:45
 modified2016-08-08 09:39:18
 2(array)
 id349
 application_id537
 given_nameCaren
 middle_name
 family_nameEmadu
 qualificationMBChB, M.Med (Paeds)
 professional_addressMama Lucy Kibaki Hospital Kayole
 telephone0722919084
 emailemaduuc@gmail.com
 created2016-08-01 10:47:45
 modified2016-08-08 09:39:18
 SiteDetail(array)
 0(array)
 id414
 application_id537
 county_id47
 site_nameMbagathi District Hospital
 physical_addressMbagathi District Hospital Ngumo Estate Mbagathi Way Nairobi- Kenya
 contact_details0722975048
 contact_personDavid Kimutai
 site_capacity(null)
 misc(null)
 created2016-08-01 10:47:45
 modified2016-08-08 09:39:18
 County(array)
 id47
 county_nameNairobi City
 created2012-06-15 10:27:40
 modified2012-06-15 10:27:40
 1(array)
 id417
 application_id537
 county_id47
 site_nameMama Lucy Kibaki Hospital
 physical_addressMama Lucy Kibaki Hospital Kayole Nairobi- Kenya
 contact_details0722919084
 contact_personCaren Emadu
 site_capacity(null)
 misc(null)
 created2016-08-02 11:19:30
 modified2016-08-08 09:39:18
 County(array)
 id47
 county_nameNairobi City
 created2012-06-15 10:27:40
 modified2012-06-15 10:27:40
 Sponsor(array)
 0(array)
 id277
 application_id537
 sponsorUNIVERSAL CORPORATION LTD
 sponsor_type(null)
 contact_person
 addressP.O. Box 1748-00902
 telephone_number254202700632
 fax_number
 cell_number0733513075
 email_addresspalu@ucl.co.ke
 created2016-08-01 10:47:45
 modified2016-08-08 09:39:18
 1(array)
 Application(array)
 id999
 user_id686
 trial_status_id(null)
 abstract_of_study\n Type of study: A single blind partially randomized controlled cross-over design\n\n Problem: Zinc deficiency is estimated to attribute to over 800,000 child deaths per year. Zinc deficiency especially affects children in developing countries where the diet is mainly cereal based. The high prevalence of deficiencies in this group can be related to increased needs during growth and development and a low dietary intake. Increasing dietary diversity and home fortification are two of the main strategies used to increase the intake of zinc. Increasing dietary diversity can be achieved by adding locally available and culturally acceptable foods to the diet. Insects are of high nutritional value and a sustainable source of minerals, and therefore an ideal candidate for enriching the diet of these young children. Evidence of house crickets as a viable source of absorbable dietary zinc is lacking therefore this study will be the first to determine zinc absorption from insects in humans.\n\n Objectives: The main objective is to assess the total absorbed zinc (TAZ) from freeze-dried house crickets added to non-refined maize porridge in comparison with a plain porridge in young children (24-36 months). Secondary objectives are to: compare the TAZ from freeze-dried house crickets added to non-refined maize porridge to the TAZ from protein powder extracted from crickets, added to non-refined maize porridge; and to compare the TAZ from freeze-dried house crickets added to non-refined maize porridge to the TAZ from ZnSO4 (the best available form) added to non-refined maize porridge.\n\n Methodology: Thirty-two eligible young children, 24-36 months old recruited from the Ober Kamoth subdistrict hospital under 5s clinic will be exposed to four different test meals, two per test day comprising maize porridge, mixed with: crickets (test meal (TM 1), ZnSO4 (TM 2), protein powder extracted from crickets (TM 3), or with no additions (TM 4). The test meals will be labelled with different stable zinc isotopes: either 68Zn (TM 1 and 3) or 67Zn (TM 2 and 4). A baseline venous blood sample and a urine sample will be collected on each test day, and spot urine samples collected on two consecutive days after the test day. Every test day one intravenous dose of labelled zinc (70Zn) will be given. There will be a one-month washout period between test days giving a study duration of 36 days. Serum Zn, CRP, AGP, ferritin and soluble transferrin receptor will be assessed in the blood sample. Zn isotope ratios determined by the dual isotope tracer ratio (DITR) technique in the spot urine samples, will be used to calculate the TAZ from each meal. The main study endpoint is the TAZ from house crickets in a non-refined maize porridge relative to the TAZ of the usual porridge. The secondary study endpoint is the TAZ from protein powder extracted from crickets and added to a non-refined maize porridge and from porridge where ZnSO4 is added.\n\n Expected findings: We expect the protein powder to have a higher TAZ compared to the house cricket porridge, since the zinc will be better bioavailable.\n\n Dissemination plan: All participants will receive their laboratory results. After final study analyses, we will share the final report and any published paper or published study findings with all interested parties listed in the protocol.\n\n \n
 study_title\n Zinc isotope study: Assessing Zinc absorption from edible insects in young children\n
 laymans_summary\n Type of study: A single blind partially randomized controlled cross-over design\n\n Problem: Zinc deficiency is estimated to attribute to over 800,000 child deaths per year. Zinc deficiency especially affects children in developing countries where the diet is mainly cereal based. The high prevalence of deficiencies in this group can be related to increased needs during growth and development and a low dietary intake. Strategies to increase the intake of zinc include increasing dietary diversity and home fortification amongst others. Increasing dietary diversity can be achieved by adding locally available and culturally acceptable foods to the diet. Insects are of high nutritional value and a sustainable source of minerals, and therefore an ideal candidate for enriching the diet of these young children. This study will be the first to determine zinc absorption from insects in humans.\n\n Objectives: The main objective is to assess the total absorbed zinc (TAZ) from freeze-dried house crickets added to non-refined maize porridge in comparison with a plain porridge in young children (24-36 months). Secondary objectives consist of: the comparison of the TAZ from freeze-dried house crickets added to non-refined maize porridge to the TAZ from protein powder extracted from crickets and added to non-refined maize porridge. In addition, the TAZ from freeze-dried house crickets added to non-refined maize porridge is compared to the TAZ from ZnSO4 (the best available form) added to non-refined maize porridge.\n\n Methodology: Research subjects (young children, 24-36 months old) will be exposed to four different test meals, two per test day. The four test meals all contain maize porridge, mixed with crickets, protein powder extracted from crickets, ZnSO4, or no additions. The test meals will be labelled with different stable zinc isotopes. Every test day one intravenous dose of labelled zinc will be given. Using the Zn isotope ratios in the urine, collected on day three and four after consumption of the test meal, the total absorbed zinc can be calculated from each meal. \n\n Expected findings: The main study endpoint is the TAZ from house crickets in a non-refined maize porridge compared to the TAZ of the usual porridge. This is assessed through isotope analysis of zinc present in spot urine samples. The secondary study endpoint is the TAZ from protein powder extracted from crickets and added to a non-refined maize porridge and from a porridge where ZnSO4 is added (the best bioavailable form of Zn). This is assessed through isotope analysis of zinc present in spot urine samples. We expect the protein powder to have a higher TAZ compared to the house cricket porridge, since the zinc will be better bioavailable.\n\n Dissemination plan: Within the field, all participants will receive their laboratory results. After final study analyses, we will share the final report and any published paper or published study findings with all interested parties listed in the protocol.\n
 short_titleZAZA study
 protocol_noECCT/21/05/01
 version_no4.0
 date_of_protocol10-03-2021
 study_drugFreeze-dried and crushed edible house crickets intrinsically labelled with 67Zn added to unrefined maize porridge.
 disease_conditionZinc deficiency
 product_type_biologicals1
 product_type_proteins1
 product_type_immunologicals0
 product_type_vaccines0
 product_type_hormones0
 product_type_toxoid0
 product_type_chemical0
 product_type_medical_device0
 product_type_chemical_name
 product_type_medical_device_name
 comparatorNo
 comparator_name
 comparator_registered
 comparator_countries
 ecct_not_applicable0
 ecct_ref_number
 email_addresstele.boit@wur.nl
 applicant_covering_letter1
 applicant_protocol1
 applicant_patient_information1
 applicant_investigators_brochure1
 applicant_investigators_cv1
 applicant_signed_declaration1
 applicant_financial_declaration1
 applicant_gmp_certificate1
 applicant_indemnity_cover1
 applicant_opinion_letter1
 applicant_approval_letter1
 applicant_statement1
 applicant_participating_countries(null)
 applicant_addendum0
 applicant_fees1
 applicant_complete_form(null)
 applicant_impd1
 applicant_prev_data1
 applicant_stability_data1
 applicant_analysis_cert1
 applicant_pictorial_sample1
 applicant_gcp_training1
 applicant_dsmb_charter1
 applicant_detailed_budget1
 applicant_indemnity_pi1
 applicant_practice_license1
 applicant_registration_ctr(null)
 applicant_pan_african1
 applicant_hard_copies(null)
 applicant_signed_checklist1
 statistical_analysis_plan1
 applicant_contractual_agreement1
 declaration_applicantTele Boit
 declaration_date103-05-2021
 declaration_principal_investigatorDr. Alida Melse- Boonstra- Principal Investigator
 declaration_date203-05-2021
 placebo_presentNo
 study_objectives\n Primary Objective:\n<ul>\n <li>\n To assess the total absorbed zinc (TAZ) from freeze-dried house crickets added to non-refined maize porridge in comparison with a plain porridge in young children (24-36 months) in South-West Kisumu County, Kisumu, Kenya.</li>\n</ul>\n\n \n\n Secondary Objectives:\n<ul>\n <li>\n To compare the TAZ from freeze-dried house crickets added to non-refined maize porridge to the TAZ protein powder extracted from crickets and added to non-refined maize porridge in young children (24-36 months).</li>\n <li>\n To compare the TAZ from freeze-dried house crickets added to non-refined maize porridge to the TAZ from ZnSO4 (the best available form) added to non-refined maize porridge in young children (24-36 months).</li>\n</ul>\n\n \n\n \n
 principal_inclusion_criteria\n Children are eligible for participation in this study if they meet all of the following criteria:\n<ul>\n <li>\n Apparently healthy young children</li>\n <li>\n Age between 24-36 months</li>\n <li>\n Willing to consume edible house crickets</li>\n <li>\n Not be wasted (weight-for-height z-score >-2) or severely stunted (height-for-age z-score >-3) (WHO 2006 growth standards)</li>\n <li>\n Signed informed consent by guardian</li>\n</ul>\n\n \n
 principal_exclusion_criteria\n A potential participant will be excluded in case he/she meets any of the following criteria:\n<ul>\n <li>\n Having consumed vitamin and mineral supplements <2 weeks before start of the study (including milk formula, MNPs or other nutrient fortified products)</li>\n <li>\n Current metabolic, gastrointestinal or chronic diseases (reported by guardians)</li>\n <li>\n Taking any long-term medication</li>\n <li>\n P. falciparum malaria infection</li>\n <li>\n Elevated concentration of C-reactive protein (defined as CRP >5 mg/L)</li>\n <li>\n Anaemia (defined as Hb <7g/dl)</li>\n <li>\n Known food allergies related to the intervention meals: Allergic to crustaceans; meaning no allergies for amongst others: crabs, lobsters, crayfish, shrimps and prawns. </li>\n <li>\n Reported medically prescribed diet</li>\n <li>\n Breastfed children (≥1 time per day)</li>\n</ul>\n\n \n
 primary_end_points<ul>\n <li>\n To assess the total absorbed zinc (TAZ) from freeze-dried house crickets added to non-refined maize porridge in comparison with a plain porridge in young children (24-36 months) in South-West Kisumu County, Kisumu, Kenya.</li>\n</ul>\n\n \n
 scope_diagnosis0
 scope_prophylaxis0
 scope_therapy0
 scope_safety0
 scope_efficacy0
 scope_pharmacokinetic0
 scope_pharmacodynamic0
 scope_bioequivalence1
 scope_dose_response0
 scope_pharmacogenetic0
 scope_pharmacogenomic0
 scope_pharmacoecomomic0
 scope_others0
 scope_others_specify
 trial_human_pharmacology0
 trial_administration_humans0
 trial_bioequivalence_study1
 trial_other0
 trial_other_specify
 trial_therapeutic_exploratory0
 trial_therapeutic_confirmatory0
 trial_therapeutic_use0
 design_controlledYes
 site_capacity(null)
 staff_numbers\n STAFF ( All Diploma holders):\n<ul>\n <li>\n 4 Clinical Officers</li>\n <li>\n 9 Nursing Officers</li>\n <li>\n 4 Lab technologists</li>\n <li>\n 2 Phramacy technologists</li>\n <li>\n 1 Public health Officers</li>\n</ul>\n\n OTHER STAFF:\n<ul>\n <li>\n 2 Community Health Extension workers</li>\n <li>\n 5 Health Service Counsellors</li>\n <li>\n 1 Clerk</li>\n <li>\n 1 Health Administration Officer</li>\n <li>\n 7 Support staff</li>\n</ul>\n\n FACILITIES ( With Water and Electricity):\n<ul>\n <li>\n Outpatient</li>\n <li>\n Impatient</li>\n <li>\n Maternity Ward</li>\n <li>\n Medical Ward</li>\n <li>\n Postnatal</li>\n</ul>\n\n \n
 other_details_explanation\n N/A\n
 other_details_regulatory_notapproved\n N/A\n
 other_details_regulatory_approved\n University of Nairobi- Kenyatta National Hospital Ethics Research Comittee. Approval number: KNH-ERC/ A/49. Approval date: 10/02/2021\n
 other_details_regulatory_rejected
 other_details_regulatory_halted
 estimated_duration3 months
 design_controlled_randomisedYes
 design_controlled_openNo
 design_controlled_single_blindYes
 design_controlled_double_blindNo
 design_controlled_parallel_groupNo
 design_controlled_cross_overYes
 design_controlled_otherNo
 design_controlled_specify
 design_controlled_comparatorZnSO4 labelled with 68Zn
 design_controlled_other_medicinalYes
 design_controlled_placeboNo
 design_controlled_medicinal_otherYes
 design_controlled_medicinal_specifyIntra-venous 9.5ml Saline solution containing 0.2mg 70Zn
 single_site_member_stateYes
 location_of_areaOber-Kamoth sub-county hospital - Level 4 Health Facility
 single_site_physical_addressKisumu
 single_site_contact_personMr. Victor Ajumbo- Clinical Officer
 single_site_telephone+254 712525941
 multiple_sites_member_stateNo
 multiple_countriesNo
 multiple_member_states
 number_of_sites
 multi_country_list
 data_monitoring_committeeYes
 total_enrolment_per_site32
 total_participants_worldwide32
 population_less_than_18_yearsYes
 population_uteroNo
 population_preterm_newbornNo
 population_newbornNo
 population_infant_and_toddlerNo
 population_childrenYes
 population_adolescentNo
 population_above_18No
 population_adultNo
 population_elderlyNo
 gender_female1
 gender_male1
 subjects_healthyYes
 subjects_patientsNo
 subjects_vulnerable_populationsYes
 subjects_women_child_bearingNo
 subjects_women_using_contraceptionNo
 subjects_pregnant_womenNo
 subjects_nursing_womenNo
 subjects_emergency_situationNo
 subjects_incapable_consentYes
 subjects_specifyChildren aged 2-3 years
 subjects_othersNo
 subjects_others_specify
 investigator1_given_nameDr. Pauline Andang\'o
 investigator1_middle_name
 investigator1_family_nameAndang\'o
 investigator1_qualificationSenior Lecturer
 investigator1_professional_addressP.O.Box 333, Maseno, Kenya
 investigator1_telephone+254728485729
 investigator1_emailaandango@maseno.ac.ke
 organisations_transferred_No
 number_participants32
 notification\n 1. ZAZA study protocol:This is the latest version of the study protocol with amendments highlighted in light blue. The study protcol amendment is awaiting approval from the UON-KNH Ethical Research Committee. \n\n 2. Co-Investigator: THis is a letter confirming that Dr. Pauline Andang'o is the Co-PI of the ZAZA study and Affiliated with Maseno University. \n\n \n
 approval_date31-08-2021
 submitted1
 deleted0
 deleted_date(null)
 deactivated0
 date_submitted09-06-2021
 is_child0
 unsubmitted0
 initial_date_submitted(null)
 admin_stopped0
 admin_stopped_reason(null)
 approved2
 approved_reasonThe application has been approved by the experts
 final_report(null)
 implication_results(null)
 quantity_imported(null)
 quantity_dispensed(null)
 quantity_destroyed(null)
 quantity_exported(null)
 balance_site(null)
 final_date(null)
 modified2021-08-31 08:39:01
 created2021-04-28 10:09:39
 total_sites(null)
 ecitizen_invoice(null)
 InvestigatorContact(array)
 0(array)
 id646
 application_id999
 given_nameDr. Alida Melse-Boonstra
 middle_name
 family_nameMelse-Boonstra
 qualificationAssociate Professor- Wageningen University and Research
 professional_addressDivision of Human Nutrition and Health, Wageningen University & Research, PO Box 9101, 6700 HB Wageningen, the Netherlands.
 telephone+31 317 484 317
 emailalida.melse@wur.nl
 created2021-04-29 18:19:07
 modified2021-06-09 09:36:45
 SiteDetail(array)
 0(array)
 id893
 application_id999
 county_id(null)
 site_name
 physical_address
 contact_details
 contact_person
 site_capacity(null)
 misc(null)
 created2021-04-29 18:19:07
 modified2021-06-09 09:36:45
 County(empty)
 Sponsor(array)
 0(array)
 id495
 application_id999
 sponsorMaseno University
 sponsor_typeResearch Institution
 contact_personDr. Pauline Andang\'o
 addressP.O. Box 333, Maseno, Kenya.
 telephone_number+254 057351622
 fax_number
 cell_number+254 728485729
 email_addressaandango@maseno.ac.ke
 created2021-04-29 18:19:07
 modified2021-06-09 09:36:45
- page_options(array)
 55
 1010
- redir
- $request->data(array)
 Application(array)
 approved2
- $this->validationErrors(array)
 Permission(empty)
 Aro(empty)
 Aco(empty)
 Application(empty)
 User(empty)
 TrialStatus(empty)
 InvestigatorContact(empty)
 Sponsor(empty)
 SiteDetail(empty)
 County(empty)
- Loaded Helpers(array)
 0Html
 1Form
 2Session
 3Text
 4Number
 5SimpleGraph
 6Paginator
 7DebugTimer
 8Toolbar
 9HtmlToolbar
====

Environment

App Constants

Constant	Value
MEDIA	'/var/www/html/ctr/app/webroot/media/'
MEDIA_STATIC	'/var/www/html/ctr/app/webroot/media/static/'
MEDIA_FILTER	'/var/www/html/ctr/app/webroot/media/filter/'
MEDIA_TRANSFER	'/var/www/html/ctr/app/webroot/media/transfer/'
MEDIA_URL	'media/'
MEDIA_STATIC_URL	'media/static/'
MEDIA_FILTER_URL	'media/filter/'
MEDIA_TRANSFER_URL	'media/transfer/'
HTTP_HOST	'ctr.pharmacyboardkenya.org'
HTTP_BASE	'http://ctr.pharmacyboardkenya.org'
HTTP_SELF	'/app/webroot/index.php'
HTTP_URI	'/applications/index/page:101/sort:study_title/direction:asc/approved:2'
CHOWN_PUBLIC	(int) 504
LF	''
NL	''
CR	''
TB	''
BR	' '
WINDOWS	false
FORMAT_DB_DATETIME	'Y-m-d H:i:s'
FORMAT_DB_DATE	'Y-m-d'
FORMAT_DB_TIME	'H:i:s'
DEFAULT_DATETIME	'0000-00-00 00:00:00'
DEFAULT_DATE	'0000-00-00'
DEFAULT_TIME	'00:00:00'
FILES	'/var/www/html/ctr/app/files/'
LOCALE	'/var/www/html/ctr/app/locale/'
CLASS_USER	'User'
VALID_ALPHA	'/^[a-zA-Z]+$/'
VALID_ALPHA_UNDERSCORES	'/^[a-zA-Z_]+$/'
VALID_ALPHA_MINUS_UNDERSCORES	'/^[a-zA-Z_-]+$/'
VALID_ALPHA_WHITESPACES	'/^[a-zA-Z ]+$/'
VALID_ALPHANUMERIC_UNDERSCORES	'/^[\da-zA-Z_]+$/'
VALID_ALPHANUMERIC_MINUS_UNDERSCORES	'/^[\da-zA-Z_-]+$/'
VALID_ALPHANUMERIC_WHITESPACES	'/^[\da-zA-Z ]+$/'
VALID_ALPHANUMERIC_WHITESPACES_UNDERSCORES	'/^[\da-zA-Z _]+$/'
VALID_NUMERIC_UNDERSCORES	'/^[\d_]+$/'
VALID_NUMERIC_WHITESPACES	'/^[\d ]+$/'
VALID_NUMERIC_WHITESPACES_UNDERSCORES	'/^[\d _]+$/'
VALID_INTEGERS	'/^[\d]+$/'
FORMAT_NICE_YMDHMS	'd.m.Y, H:i:s'
FORMAT_NICE_YMDHM	'd.m.Y, H:i'
FORMAT_NICE_YM	'm.Y'
FORMAT_NICE_YMD	'd.m.Y'
FORMAT_NICE_MD	'd.m.'
FORMAT_NICE_D	'd'
FORMAT_NICE_W_NUM	'w'
FORMAT_NICE_W_ABBR	'D'
FORMAT_NICE_W_FULL	'l'
FORMAT_NICE_M	'm'
FORMAT_NICE_M_ABBR	'M'
FORMAT_NICE_M_FULL	'F'
FORMAT_NICE_Y_ABBR	'y'
FORMAT_NICE_Y	'Y'
FORMAT_NICE_HM	'H:i'
FORMAT_NICE_HMS	'H:i:s'
FORMAT_LOCAL_WA_YMDHMS	'%a, %d.%m.%Y, %H:%M:%S'
FORMAT_LOCAL_WF_YMDHMS	'%A, %d.%m.%Y, %H:%M:%S'
FORMAT_LOCAL_WA_YMDHM	'%a, %d.%m.%Y, %H:%M'
FORMAT_LOCAL_WF_YMDHM	'%A, %d.%m.%Y, %H:%M'
FORMAT_LOCAL_YMDHMS	'%d.%m.%Y, %H:%M:%S'
FORMAT_LOCAL_YMDHM	'%d.%m.%Y, %H:%M'
FORMAT_LOCAL_YMD	'%d.%m.%Y'
FORMAT_LOCAL_MD	'%d.%m.'
FORMAT_LOCAL_D	'%d'
FORMAT_LOCAL_W_NUM	'%w'
FORMAT_LOCAL_W_ABBR	'%a'
FORMAT_LOCAL_W_FULL	'%A'
FORMAT_LOCAL_M	'%m'
FORMAT_LOCAL_M_ABBR	'%b'
FORMAT_LOCAL_M_FULL	'%B'
FORMAT_LOCAL_Y_ABBR	'%y'
FORMAT_LOCAL_YMS_ABBR	'%d.%m.%y'
FORMAT_LOCAL_Y	'%Y'
FORMAT_LOCAL_H	'%H'
FORMAT_LOCAL_S	'%S'
FORMAT_LOCAL_HM	'%H:%M'
FORMAT_LOCAL_HMS	'%H:%M:%S'
CHAR_LESS	'<'
CHAR_GREATER	'>'
CHAR_QUOTE	'"'
CHAR_APOSTROPHE	'''
CHAR_ARROWS	'»'
CHAR_ARROWS_R	'»'
CHAR_ARROWS_L	'«'
CHAR_AVERAGE	'Ø'
CHAR_INFIN	'∞'
CHAR_MILL	'‰'
CHAR_PLUSMN	'±'
CHAR_HELLIP	'…'
CHAR_CIRCA	'≈'
CHAR_CHECKBOX_EMPTY	'☐]'
CHAR_CHECKBOX_MAKRED	'☑'
CHAR_CHECKMARK	'✓'
CHAR_CHECKMARK_BOLD	'✔'
CHAR_BALLOT	'✗'
CHAR_BALLOT_BOLD	'✘'
CHAR_ABOUT	'≈'
CHAR_RPIME	'′'
CHAR_DOUBLE_RPIME	'″'

CakePHP Constants

Constant	Value
APP	'/var/www/html/ctr/app/'
APP_DIR	'app'
APPLIBS	'/var/www/html/ctr/app/Lib/'
CACHE	'/var/www/html/ctr/app/tmp/cache/'
CAKE	'/var/www/html/ctr/lib/Cake/'
CAKE_CORE_INCLUDE_PATH	'/var/www/html/ctr/lib'
CORE_PATH	'/var/www/html/ctr/lib/'
CAKE_VERSION	'2.2.2'
CSS	'/var/www/html/ctr/app/webroot/css/'
CSS_URL	'css/'
DS	'/'
FULL_BASE_URL	'https://ctr.pharmacyboardkenya.org'
IMAGES	'/var/www/html/ctr/app/webroot/img/'
IMAGES_URL	'img/'
JS	'/var/www/html/ctr/app/webroot/js/'
JS_URL	'js/'
LOGS	'/var/www/html/ctr/app/tmp/logs/'
ROOT	'/var/www/html/ctr'
TESTS	'/var/www/html/ctr/app/Test/'
TMP	'/var/www/html/ctr/app/tmp/'
VENDORS	'/var/www/html/ctr/vendors/'
WEBROOT_DIR	'webroot'
WWW_ROOT	'/var/www/html/ctr/app/webroot/'

PHP Environment

Environment Variable	Value
Php Version	'5.6.40-81+ubuntu20.04.1+deb.sury.org+1'
Redirect Redirect Https	'on'
Redirect Redirect Ssl Tls Sni	'ctr.pharmacyboardkenya.org'
Redirect Redirect Status	'200'
Redirect Https	'on'
Redirect Ssl Tls Sni	'ctr.pharmacyboardkenya.org'
Redirect Status	'200'
Https	'on'
Ssl Tls Sni	'ctr.pharmacyboardkenya.org'
Http Accept	'/'
Http User Agent	'Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)'
Http Accept Encoding	'gzip, br, zstd, deflate'
Http Host	'ctr.pharmacyboardkenya.org'
Path	'/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin'
Server Signature	' Apache/2.4.41 (Ubuntu) Server at ctr.pharmacyboardkenya.org Port 443 '
Server Software	'Apache/2.4.41 (Ubuntu)'
Server Name	'ctr.pharmacyboardkenya.org'
Server Addr	'192.168.10.21'
Server Port	'443'
Remote Addr	'3.12.149.233'
Document Root	'/var/www/html/ctr'
Request Scheme	'https'
Context Prefix	''
Context Document Root	'/var/www/html/ctr'
Server Admin	'webmaster@localhost'
Script Filename	'/var/www/html/ctr/app/webroot/index.php'
Remote Port	'17306'
Redirect Url	'/app/webroot/applications/index/page:101/sort:study_title/direction:asc/approved:2'
Gateway Interface	'CGI/1.1'
Server Protocol	'HTTP/1.1'
Request Method	'GET'
Query String	''
Request Uri	'/applications/index/page:101/sort:study_title/direction:asc/approved:2'
Script Name	'/app/webroot/index.php'
Php Self	'/app/webroot/index.php'
Request Time Float	(float) 1746149873.349
Request Time	(int) 1746149873

====

Include
+
Included Files

Include Paths
- 0/var/www/html/ctr/app/Plugin/Media/Lib/mm/src
- 1/var/www/html/ctr/lib
- 3/usr/share/php
- 4-> /var/www/html/ctr/lib/Cake/
Included Files
- core(array)
  Behavior(array)
  0CORE/Model/Behavior/TreeBehavior.php
  1CORE/Model/Behavior/ContainableBehavior.php
  2CORE/Model/Behavior/AclBehavior.php
  Cache(array)
  0CORE/Cache/Cache.php
  1CORE/Cache/Engine/FileEngine.php
  2CORE/Cache/CacheEngine.php
  Component(array)
  0CORE/Controller/Component/AclComponent.php
  1CORE/Controller/Component/Acl/DbAcl.php
  2CORE/Controller/Component/Acl/AclInterface.php
  3CORE/Controller/Component/AuthComponent.php
  4CORE/Controller/Component/RequestHandlerComponent.php
  5CORE/Controller/Component/SessionComponent.php
  6CORE/Controller/Component/PaginatorComponent.php
  Config(array)
  0CORE/Config/routes.php
  1CORE/Config/config.php
  Controller(array)
  0CORE/Controller/Controller.php
  1CORE/Controller/ComponentCollection.php
  2CORE/Controller/Component.php
  Datasource(array)
  0CORE/Model/Datasource/CakeSession.php
  1CORE/Model/Datasource/Database/Mysql.php
  2CORE/Model/Datasource/DboSource.php
  3CORE/Model/Datasource/DataSource.php
  Error(array)
  0CORE/Error/exceptions.php
  1CORE/Error/ErrorHandler.php
  I18n(array)
  0CORE/I18n/I18n.php
  1CORE/I18n/L10n.php
  Log(array)
  0CORE/Log/CakeLog.php
  1CORE/Log/LogEngineCollection.php
  2CORE/Log/Engine/FileLog.php
  3CORE/Log/Engine/BaseLog.php
  4CORE/Log/CakeLogInterface.php
  Model(array)
  0CORE/Model/ConnectionManager.php
  1CORE/Model/Permission.php
  2CORE/Model/Model.php
  3CORE/Model/BehaviorCollection.php
  4CORE/Model/Aro.php
  5CORE/Model/AclNode.php
  6CORE/Model/Aco.php
  7CORE/Model/ModelBehavior.php
  Network(array)
  0CORE/Network/CakeRequest.php
  1CORE/Network/CakeResponse.php
  Other(array)
  0CORE/bootstrap.php
  1CORE/basics.php
  2CORE/Core/App.php
  3CORE/Core/Configure.php
  4CORE/Core/CakePlugin.php
  5CORE/Event/CakeEventListener.php
  6CORE/Event/CakeEvent.php
  7CORE/Event/CakeEventManager.php
  8CORE/Core/Object.php
  Routing(array)
  0CORE/Routing/Dispatcher.php
  1CORE/Routing/Filter/AssetDispatcher.php
  2CORE/Routing/DispatcherFilter.php
  3CORE/Routing/Filter/CacheDispatcher.php
  4CORE/Routing/Router.php
  5CORE/Routing/Route/CakeRoute.php
  6CORE/Routing/Route/PluginShortRoute.php
  Utility(array)
  0CORE/Utility/Hash.php
  1CORE/Utility/Inflector.php
  2CORE/Utility/ObjectCollection.php
  3CORE/Utility/Debugger.php
  4CORE/Utility/String.php
  5CORE/Utility/ClassRegistry.php
  6CORE/Utility/Set.php
  7CORE/Utility/Sanitize.php
  View(array)
  0CORE/View/HelperCollection.php
- app(array)
  Behavior(array)
  0APP/Model/Behavior/SoftDeleteBehavior.php
  Config(array)
  0APP/Config/core.php
  1APP/Config/bootstrap.php
  2APP/Config/routes.php
  3APP/Config/database.php
  Controller(array)
  0APP/Controller/ApplicationsController.php
  1APP/Controller/AppController.php
  Model(array)
  0APP/Model/AppModel.php
  1APP/Model/Application.php
  2APP/Model/User.php
  3APP/Model/TrialStatus.php
  4APP/Model/InvestigatorContact.php
  5APP/Model/Sponsor.php
  6APP/Model/SiteDetail.php
  7APP/Model/County.php
  Other(array)
  0APP/webroot/index.php
- plugins(array)
  CakePdf(array)
  Config(array)
  0CakePdf/Config/bootstrap.php
  1CakePdf/Config/routes.php
  CakeResque(array)
  Config(array)
  0CakeResque/Config/bootstrap.php
  Plugin(array)
  0CakeResque/Lib/CakeResque.php
  1CakeResque/vendor/kamisama/php-resque-ex/lib/Resque.php
  2CakeResque/vendor/kamisama/php-resque-ex/lib/Resque/Event.php
  3CakeResque/vendor/kamisama/php-resque-ex/lib/Resque/Exception.php
  DebugKit(array)
  Component(array)
  0DebugKit/Controller/Component/ToolbarComponent.php
  Plugin(array)
  0DebugKit/Lib/DebugMemory.php
  1DebugKit/Lib/Panel/HistoryPanel.php
  2DebugKit/Lib/DebugPanel.php
  3DebugKit/Lib/Panel/SessionPanel.php
  4DebugKit/Lib/Panel/RequestPanel.php
  5DebugKit/Lib/Panel/SqlLogPanel.php
  6DebugKit/Lib/Panel/TimerPanel.php
  7DebugKit/Lib/Panel/LogPanel.php
  8DebugKit/Lib/Log/Engine/DebugKitLog.php
  9DebugKit/Lib/Panel/VariablesPanel.php
  10DebugKit/Lib/Panel/EnvironmentPanel.php
  11DebugKit/Lib/Panel/IncludePanel.php
  12DebugKit/Lib/DebugTimer.php
  Media(array)
  Config(array)
  0Media/Config/bootstrap.php
  Plugin(array)
  0Media/Lib/mm/src/Mime/Type.php
  1Media/Lib/mm/src/Mime/Type/Magic/Adapter/Fileinfo.php
  2Media/Lib/mm/src/Mime/Type/Magic/Adapter.php
  3Media/Lib/mm/src/Mime/Type/Glob/Adapter/Memory.php
  4Media/Lib/mm/src/Mime/Type/Glob/Adapter.php
  5Media/Lib/mm/src/Media/Process.php
  6Media/Lib/mm/src/Media/Info.php
  Search(array)
  Component(array)
  0Search/Controller/Component/PrgComponent.php
  Behavior(array)
  0Search/Model/Behavior/SearchableBehavior.php
  Shim(array)
  Config(array)
  0Shim/Config/bootstrap.php
  Tools(array)
  Config(array)
  0Tools/Config/bootstrap.php
====

Clinical Trial Applications: Filter, Search, and view applications {lang: 'en-GB'}

Request History

Session

Request

Cake Params

Post data

Query string

Cookie

Current Route

Sql Logs

default

Total Time: 149 ms Total Queries: 8 queries

Query Explain:

Memory

Timers

Logs

View Variables

App Constants

CakePHP Constants

PHP Environment

Included Files

Include Paths

Included Files

Clinical Trial Applications: Filter, Search, and view applications

Total Time: 149 ms
Total Queries: 8 queries